Neuropeptide Deep Crease Serum, 1 oz.

4.5 (662)
$189.00
Size:1.00 oz
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Product details

Web ID: 25409545
Targeted skin refinement begins with this Perricone MD Neuropeptide Deep Crease Serum focused on improving the look of lines around the mouth, eyes, lips, and forehead. Neuropeptides and plant stem cells help support wrinkle reduction and improve the appearance of skin density for a smoother look.

  • Product Features

    • WHAT IT IS:
    • A highly-potent silky serum.
    • WHAT IT DOES:
    • Helps smooth the look of even the most stubborn, deep lines, wrinkles, and creases around the mouth, eyes, lips & forehead. Reduces the appearance of deep creases, marionette & lip lines.
    • INGREDIENT HIGHLIGHTS:
    • Formulated with neuropeptides, peptides
    • SKIN TYPES:
    • Suitable for all skin types
    • HOW TO USE:
    • After cleansing, massage onto face & neck using a gentle upward motion. Wait until fully absorbed & follow with your favorite Perricone MD moisturizer. Use morning and evening.

  • Shipping & Returns

    • This item qualifies for Free Shipping with minimum purchase! exclusions & details
    • California and Minnesota customers call 1-800-289-6229 for Free Shipping information.
    • For complete details, see our Shipping and Returns policies.
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More about the product

Ratings & Reviews

Here's what customers think
  • The Perricone MD Neuropeptide Deep Crease Serum is an effective anti-aging product that helps visibly reduce the appearance of deep wrinkles and creases.
  • Customers report the serum smooths and softens expression lines, leaving the skin looking more youthful.
  • The luxurious, silky formula absorbs quickly without residue and is formulated with neuropeptides, biomimetic growth factor peptides, and plant stem cells to boost skin elasticity and target stubborn wrinkles.
  • Many users noted an immediate improvement in the appearance of fine lines and deeper creases, with continued use leading to even more noticeable results over time.
AI-generated summary from 662 customers reviews.
4.5/5

662 star ratings & reviews

Write a Review
65.9% of reviews have 5 stars
436
22.2% of reviews have 4 stars
147
9.5% of reviews have 3 stars
63
1.8% of reviews have 2 stars
12
0.6% of reviews have 1 star
4

1224 customer images

662 reviews
StephanieS
5 days ago
Incentivized review

Great for expression lines!

I’ve been really enjoying the Perricone MD Neuropeptide Deep Crease Serum. The texture is light weight and absorbs quickly without any stickiness. I really like the subtle rose scent. Nasolabial folds and marionette lines have been a growing concern of mine lately, and after about 3 weeks of consistent use I’ve noticed a visible difference. Those areas look smoother and less pronounced. That alone makes it feel worth incorporating into my daily routine and I’m excited to see what long term use brings. A couple downsides keeping me from bringing it to a full five stars. The dropper isn’t great and doesn’t dispense product easily, it almost makes me wonder if I possibly received a defective dropper. I’ve also noticed slight pilling, especially if I layer too quickly or use certain products on top. That said the formula itself clearly works and it’s still a serum I would definitely recommend.

Customer review from influenster.com

KristinC
5 days ago
Incentivized review

Not a game changer.

This product is fine. I don’t have a lot of wrinkles, but I didn’t notice a change in any of the few that I do (mid-thirties). I will say that this product had a dropper in it and it did not work, which was agitating. The product went on well and was not thick or sticky, and it didn’t have much of a scent. Not something I will ever go out of my way to buy.

Customer review from influenster.com

ChristineG
5 days ago
Incentivized review

Anti aging without irritation

Love this luxury anti aging serum that goes on easily and is lightweight. I have a smoother more refreshed look over time! You can feel well hydrated and plumper with each application. I have sensitive skin and felt like I could tolerate this product with no issues. Love this brand

Customer review from influenster.com

JessicaB
5 days ago
Incentivized review

Your skin will DRINK it!!

The Neuropeptide Deep Crease Serum by Perricone MD is amazing. Honestly, each product I try from them makes me love them more and more. This serum soaks in immediately and leave your skin feeling like just hydrated skin. No residue at all. It is gentle and will fold right into your skincare routine. I can’t wait to see the long term benefits. Oh and it’s smells so good!!

Customer review from influenster.com

ShilpaL
5 days ago
Incentivized review

Effective on small Creases

I got this product free in exchange for my honest reviews. I am using this serum along with other perricone MD products. The serum definitely helps to fill the small small creases but nothing helping so far with my wrinkles. The scent is awful but stays for 2-3 second and then vanish so I don’t mind much. No side effects so far. Come with easy to use dropper.

Customer review from influenster.com

MelindaM
5 days ago
Incentivized review

New staple

I love this product. I was not very optimistic about it improving my deeper creases but it surprised me. I’m not saying that it permanently removes them but it does a great job of plumping up your skin to make them less noticeable. Maybe with time it will become more permanent. The bottle is sometimes harder to get the thick product into the tube to dispense the product but that is my only negative. The consistency of the product is nice and absorbs well. It is not an offensive scent which increases my likelihood of continuing to use it. I will be adding this to my routine and repurchasing it.

Customer review from influenster.com

MarisaR
5 days ago
Incentivized review

A beautiful serum

This is so nice. I'm not sure it's made great headway on my deep creases but it has helped keep my skin happy and moisturized through a very cold and dry winter with no irritation. I've been using it for at least a month and I still have more than half a bottle left, so that's a good value. Smells nice, spreads and absorbs beautifully, doesn't fight with other products on top of it.

Customer review from influenster.com

External reviewer
5 days ago
Incentivized review

Smooth and hydrating

This serum is super hydrating! I’ve been using it for a few weeks but haven’t seen major benefits in wrinkle reduction, but I do love the way it hydrates my skin. It’s smooth and easy to apply. Not oily or heavy feeling. Just a few drops in areas of concern is all you need. It spreads nicely and doesn’t leave an oily feeling.

Customer review from influenster.com