Neuropeptide Deep Crease Serum, 1 oz.

4.5 (707)
$160.65 (15% off) with code: VIP$189.00
Size:1.00 oz
Offers & perks
Free gift with purchase
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Product details

Web ID: 25409545
Targeted skin refinement begins with this Perricone MD Neuropeptide Deep Crease Serum focused on improving the look of lines around the mouth, eyes, lips, and forehead. Neuropeptides and plant stem cells help support wrinkle reduction and improve the appearance of skin density for a smoother look.

  • Product Features

    • WHAT IT IS:
    • A highly-potent silky serum.
    • WHAT IT DOES:
    • Helps smooth the look of even the most stubborn, deep lines, wrinkles, and creases around the mouth, eyes, lips & forehead. Reduces the appearance of deep creases, marionette & lip lines.
    • INGREDIENT HIGHLIGHTS:
    • Formulated with neuropeptides, peptides
    • SKIN TYPES:
    • Suitable for all skin types
    • HOW TO USE:
    • After cleansing, massage onto face & neck using a gentle upward motion. Wait until fully absorbed & follow with your favorite Perricone MD moisturizer. Use morning and evening.

  • Shipping & Returns

    • This item qualifies for Free Shipping with minimum purchase! exclusions & details
    • California and Minnesota customers call 1-800-289-6229 for Free Shipping information.
    • For complete details, see our Shipping and Returns policies.

Ratings & Reviews

Here's what customers think
  • The Neuropeptide Deep Crease Serum is an effective anti-aging product that helps smooth and soften the appearance of deep wrinkles and expression lines.
  • Users reported noticeable improvements in the depth and visibility of lines after consistent use.
  • The serum has a luxurious, silky texture that absorbs quickly without leaving a greasy or sticky residue.
  • It is formulated with neuropeptides, biomimetic growth factor peptides, and plant stem cells to help boost skin elasticity and reduce the look of deep creases.
  • Many users found the serum to be hydrating and leave their skin looking more plump and radiant.
AI-generated summary from 707 customers reviews.
4.5/5

707 star ratings & reviews

Write a Review
65.1% of reviews have 5 stars
460
23.1% of reviews have 4 stars
163
9.5% of reviews have 3 stars
67
1.7% of reviews have 2 stars
12
0.7% of reviews have 1 star
5

1293 customer images

707 reviews
External reviewer
11 days ago
Incentivized review

Does what it says.

I am not new to Perricone MD products, so I was excited to try their deep crease serum. Especially, now that I’m older, I have seen a change in my skin. Especially the elasticity, texture, and increase in fine lines and wrinkles. I have deep smile lines that make my makeup application difficult. Using this product has made them smoother and less noticeable even without makeup use. These pictures are months apart and my no makeup look is much more improved than my makeup look. And this is without consistent nightly use. I’m very pleased with my results.

Customer review from influenster.com

MSL
11 days ago
from Indiana

Noticeable difference

I have been using for about a month and some of the wrinkles I have been concerned about are easing

Recommends this product

Customer review from Perricone MD

Response from Perricone MD

Gabriela10 days ago

Don’t hesitate to share your thoughts any time!

BrittanyQ
13 days ago
Incentivized review

Weightless plumping results

The serum was light weight and absorbed easily. It doesn’t leave any residue on skin and could easily be worn under make up. I have noticed it makes my skin feel more plump. I’m still waiting to see the long term results but I’ve notice some improvement in fine lines.

Customer review from influenster.com

AndreaG
15 days ago
Incentivized review

Potent!

I’m enjoying using this serum. I’ve been applying it on the area between my eyebrows. That’s where I’m most self conscious about my wrinkles. I’m still gauging the results. It is concentrated so a little goes a long way. I’ll keep using it to see what the final results are. So far so good!

Customer review from influenster.com

LoriC
16 days ago
Incentivized review

Feels great, pending long term results.

This serum goes on smooth and absorbs well, working well under makeup - no beading or pilling of my makeup, which I like. However, while I do like the product and will continue to use it, I can’t say I’ve seen a miraculous difference in my creases. Will continue using to see if the long term effects are noticeable.

Customer review from influenster.com

SaidaA
20 days ago
Incentivized review

Softening

This softened my skin! I haven’t used it enough to see if it helps with creases but overall I really love this product and recommend it for other people!

Customer review from influenster.com

LindsayM
20 days ago
Incentivized review

Amazing serum for fine lines/wrinkles

First of all, the packaging for this serum is consistent with all Perricone MD skincare products - A luxe but minimalist style frosted glass bottle with a pump. This serum feels lightweight and absorbs quickly without feeling sticky or greasy (and a pea sized amount goes a long way). It also does not pill when used with other skincare products. You won’t see results overnight but with consistent use, I have noticed that my fine lines are softer / less noticeable and my skin looks plumper. Finally, I experienced no irritation or sensitivity. For those sensitive to smell though, there is a slight fragrance to it but it is not overwhelming. I would highly recommend this product to anyone looking for a skincare product designed to address wrinkles/fine lines. I received this product in exchange for my honest review.

Customer review from influenster.com

ChristineS
20 days ago
Incentivized review

Deep creases be gone

I love a good serum and always looking for something that will not irritate my sensitive skin. This serum is lovely and gets in all the crevices without drying or feeling sticky.

Customer review from influenster.com