Neuropeptide Deep Crease Serum, 1 oz.

Limited-Time Special
$132.30 (30% off)$189.00Free shipping code: GLAM10
Size:1.00 oz

Product details

Web ID: 25409545

Targeted skin refinement begins with this Perricone MD Neuropeptide Deep Crease Serum focused on improving the look of lines around the mouth, eyes, lips, and forehead. Neuropeptides and plant stem cells help support wrinkle reduction and improve the appearance of skin density for a smoother look.

  • Product Features

    • WHAT IT IS:
    • A highly-potent silky serum.
    • WHAT IT DOES:
    • Helps smooth the look of even the most stubborn, deep lines, wrinkles, and creases around the mouth, eyes, lips & forehead. Reduces the appearance of deep creases, marionette & lip lines.
    • INGREDIENT HIGHLIGHTS:
    • Formulated with neuropeptides, peptides
    • SKIN TYPES:
    • Suitable for all skin types
    • HOW TO USE:
    • After cleansing, massage onto face & neck using a gentle upward motion. Wait until fully absorbed & follow with your favorite Perricone MD moisturizer. Use morning and evening.

  • Shipping & Returns

    • This item qualifies for Free Shipping with minimum purchase! exclusions & details
    • California and Minnesota customers call 1-800-289-6229 for Free Shipping information.
    • For complete details, see our Shipping and Returns policies.

Ratings & Reviews

Here's what customers think
  • Customers report skin feels significantly softer, smoother, and more hydrated with immediate, sustained improvement in radiance and plumpness.
  • Many notice visible softening of fine lines and expression wrinkles around the mouth and forehead within weeks of consistent use.
  • Reviewers praise the lightweight, silky texture that absorbs quickly without greasiness, making it ideal for daily application.
  • Most with sensitive skin report no irritation, breakouts, or redness, highlighting the formula's gentle compatibility.
  • A few mention minimal visible changes in deeper wrinkles, though most consider the serum a worthwhile luxury addition to their routine.
AI-generated summary from 732 customers reviews.
4.5/5

732 star ratings & reviews

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732 reviewssorted by Newest

dodi
8 days ago

bad batch or huge change in formulation

consistency of water for eyelift serum- i've been using for years so i know. a major hassle to get a replacement. Not Happy

Customer review from Perricone MD

Response from Perricone MD

Gabriela8 days ago

Your satisfaction is our top priority, your feedback means a lot to us and helps us continue to improve.

Jo
20 days ago

Excellent product

My skin is noticeably better and feels so smooth. This stuff is amazing

Recommends this product

Customer review from Perricone MD

Response from Perricone MD

Ankita20 days ago

Hello, we are delighted you liked this product and we thank you for sharing such a valuable feedback :)

KellyS
22 days ago
Incentivized review

Solid Peptide for Fullness

This is a great serum. Over the few months that I used it, I noticed my skin looked fuller especially around my mouth where I have deeper smile lines. The product absorbed easily and didn’t sit on top of the skin, which I appreciated. My only gripe, and it’s a small one, is the dropper. I had a difficult time consistently picking up product each night. Overall, though, it is a beautiful product that lived up to its promises.

Customer review from Perricone MD

Wrinkles
2 months ago

Deep Crease serum

This product does what it says. It has reduced my wrinkles around my mouth and helped with the creases next to my nose. It does take time. Took 3 months of use to really see the change. I am 70.

Customer review from Perricone MD

Response from Perricone MD

Perricone MD Customer Care2 months ago

Thank you for sharing your experience! We truly appreciate your support!

DawnM
2 months ago
Incentivized review

A Luxurious Serum That Delivers Lasting Hydration

After several weeks of using Clarins Neuropeptide Deep Crease Serum, I've been impressed by how elegant the formula feels on my skin. Many anti-aging serums I've tried either feel heavy or leave behind a tacky finish, but this one absorbs quickly and layers beautifully with the rest of my skincare routine. I have sensitive combination skin with occasional redness, so I'm always cautious when introducing products focused on wrinkles and firming. Thankfully, this serum felt gentle from the start and didn't cause irritation or dryness. The texture is lightweight, silky, and leaves my skin feeling smooth and hydrated rather than coated. What stood out most to me was how my skin looked overall after consistent use. My complexion appeared more refreshed and rested, and some of the deeper expression lines around my forehead seemed less pronounced when my skin was well hydrated. I also noticed a subtle improvement in skin firmness and bounce, especially in the morning. The packaging feels luxurious, and the pump dispenses the perfect amount without waste. While no serum can completely erase deep creases overnight, this formula helps my skin look healthier, smoother, and more revitalized with continued use.

Customer review from Perricone MD

cab
2 months ago

Wonderful Stuff

Neuropeptide Deep Crease Serum 30ml - Wonderful stuff. This has made a big difference to my skin and I have had a few people saying how good my skin is looking. Dropper dispenser could be improved on and a super size would be good! I have bought 4 of these!!! Neuropeptide Eyelid serum 15ml - I haven't noticed any difference but I have been using the previous eyelid lift serum. Dropper on this is fine as the serum is much more fluid. You only need a small amount and I think it will last for months.

Customer review from Perricone MD

Response from Perricone MD

Perricone MD Customer Care2 months ago

Thank you for sharing your experience! We truly appreciate your support and your thoughtful feedback.

D3
2 months ago
from IN

Disappointing

Expensive with nothing to show for it. Very basic product.

Customer review from Perricone MD

Response from Perricone MD

Perricone MD Customer Care2 months ago

Thank you for your feedback. We regret that the product did not meet your expectations. We would appreciate the opportunity to discuss this further and provide a resolution. If you wouldn't mind giving us a call at (844)334-9398 at the earliest convenience, looking forward to talking to you.

JH28
3 months ago
Incentivized review

Not worth the hype

I am not a fan of this product. First, the dropper for dispensing the product is frustrating and an inconvenient. The consistency feels far too sticky after application and my face just feels heavy and coated. Unfortunately, I did not notice any improvement on my wrinkles and overall skin texture.

Customer review from Perricone MD